Totipotent cell8/10/2023 ![]() Now, the team of Maria-Elena Torres-Padilla has studied the characteristics of totipotent cells of the embryo and found factors capable of inducing a totipotent-like state. Pluripotent cells then continue to specialise and form the various tissues of the body through a process called cellular differentiation.įor some years, it has been possible to re-programme differentiated cells into pluripotent ones, but not into totipotent cells. At the blastocyst stage (about thirty cells), the so-called “ embryonic stem cells” can differentiate into any tissue, although they alone cannot give birth to a foetus anymore. During the subsequent rounds of cell division, cells rapidly lose this plasticity and become “pluripotent”. ©Inserm/Benchoua AlexandraJust after fertilization, when the embryo is comprised of only 1 or 2 cells, cells are “ totipotent“, that is to say, capable of producing an entire embryo as well as the placenta and umbilical cord that accompany it. Human embryonic stem cells have the potential to form in vitro neural tube -like structures of the embryo. Obtained in collaboration with Juanma Vaquerizas from the Max Planck Institute for Molecular Biomedicine (Münster, Germany), these results are published on 3rd of August in the journal Nature Structural & Molecular Biology. ![]() They managed to obtain totipotent cells with the same characteristics as those of the earliest embryonic stages and with even more interesting properties. While it is already possible to obtain in vitro pluripotent cells (ie, cells capable of generating all tissues of an embryo) from any cell type, researchers from Maria-Elena Torres-Padilla’s team have pushed the limits of science even further. ![]()
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